Mobile Symphony concerts take place in the historic Saenger Theatre of Mobile.

When Mobile's Saenger Theatre opened on January 19, 1927, it was the 61st in the Saenger Theatre chain founded by JH and AD Saenger of New Orleans, and located throughout the South, as well in Cuba and Puerto Rico. Hailed as "Alabama's Greatest Showplace" and "the most beautiful playhouse in all of Dixie", the Mobile Saenger Theatre took a year to construct at a cost of about $500,000.

Through the years, the Saenger Theatre provided Mobilians outstanding theatrical entertainment on the live stage and motion picture screen. The Saenger hosted silent movies, vaudeville shows, movies, dramatic and musical productions, and was the scene of the first America's Junior Miss Pageant . However, as was the case with many of these grand movie palaces, ownership changes, high maintenance costs, and a changing city-core rendered many of these beautiful buildings "white elephants". Many were demolished to make was for parking lots and other forms of urban development. ABC/Paramount closed the Saenger Theatre and removed the projection equipment in early 1970. On the eve of demolition, the University of South Alabama bought the Saenger from ABC/Paramount, and the Theatre was renovated and re-opened as a performing arts center under the name of The USA Saenger Theatre. The University's restoration and return to operation of the Mobile Saenger Theatre is credited as having been one of the major forces in the revitalization of downtown Mobile.

On October 1, 1999, the Saenger Theatre was purchased by the City of Mobile from the University of South Alabama. The City then entered into a 30-year lease agreement with a brand new, not-for-profit organization called Centre for the Living Arts, Inc. with funding provided by the J.L. Bedsole Foundation . The summer of 2000 saw the replacement of the Theatre's heating and air-conditioning units, as well as a complete rewiring of the theatre's electrical system. Further upgrades will included the stage rigging and film projection systems, executive offices, as well as the conversion of the old retail space fronting Joachim Street into a grand lobby and concession area with updated restroom and VIP facilities.

The Saenger Theatre Performing Arts Center will function as a multi-disciplinary arts center, home of the Mobile Symphony Orchestra, the Saenger Series, the Summer Movie Series, concerts, lectures, and special events.